Posted on 16th Jun 2018 16:36:55 in CSIR NET Life Sciences
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Dr. VIPUL VAIBHAV (C.C.M.B. HYDERABAD)
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This analysis deals with the integrated domains of Molecular Biology, Viral Genetics and Genomics. Areas of applied biology including Transgenics and gene therapy etc are also included here.
These areas are highly interesting, being some of the frontier areas of research today......
Applied biology areas such as Transgenics, Gene therapy, Marker Assisted Selection (MAS) are already making an impact on our daily lives. This is possible through the application of bio-molecular and Recombinant DNA techniques and genomics. Indeed this does not end here….applying a technique to produce a product (say a GMO) may sound very glamorous and worthy of study. However in order to develop and apply technology, requires an in-depth understanding of the basic phenomenon…….in this case, Molecular Biology.
During classroom teaching, we devote 70-80hrs to these domains, supported by extensive illustrations and problem solving. As must be clear from above, students must develop a good base in the basic concepts of molecular biology to understand concepts of Genetic Engineering and applied biology.
There are no short cuts….
As we analyse the trends of the previous CSIR paper, it is clear that 5-8 questions in part B and 8-12 in part C are from these areas (see table).
|
Year |
Section B |
Section C |
|
Jun-211 |
6 |
8 |
|
Dec-11 |
6 |
5 |
|
Jun-12 |
4 |
8 |
|
Dec-12 |
7 |
12 |
|
Jun-13 |
8 |
12 |
|
Dec-13 |
7 |
8 |
|
Jun-14 |
7 |
8 |
|
Dec-14 |
5 |
9 |
|
Jun-15 |
7 |
10 |
|
Dec-15 |
5 |
9 |
|
Jun-16 |
5 |
8 |
|
Dec-16 |
6 |
11 |
|
Jun-17 |
8 |
9 |
|
Dec-17 |
6 |
8 |
We also performed topic wise analysis related to these domains.
1. It is clear that regulation of gene expression is a key area of focus in these papers. Regulation at the level of transcription, translation, and post-translational modifications are very important.
2. Operons are a frequent focus, specifically the Lac and Trp operon…and in great detail. This does not mean you can skip the other operon systems.
3. In eukaryotic regulation, the role of Regulatory RNAs such as siRNA and miRNA, RNA Interference are important. Questions on regulation of gene expression by DNA methylation and chromatin re-modelling are frequently asked.
4. All these are concept based questions. Students enjoy focusing on these areas……..….but here comes the rider….regulation is difficult to understand without understanding of the basic fundamentals of molecular biology.
5. This is reflected in the fact, that at least twice as many questions are asked from the fundamentals such as chromatin organization, Gene and genome organization, replication, DNA repair, basic transcription, RNA processing, and Translation. Question from telomeres and its significance have been asked.
TOPICWISE ANALYSIS OF QUESTIONS
|
||||||||||||||
|
Topics |
Jun-11 |
Dec-11 |
Jun-12 |
Dec-12 |
Jun-13 |
Dec-13 |
Jun-14 |
Dec-14 |
Jun-15 |
Dec-15 |
Jun-16 |
Dec-16 |
Jun-17 |
Dec-17 |
|
DNA structure, Gene and Genome Organization, chromosomes, Chromatin re-modelling, transposons |
2 |
|
|
4 |
|
|
2 |
3 |
1 |
1 |
2 |
|
2 |
|
|
Replication, Recombina-tion and Repair of DNA |
2 |
1 |
2 |
4 |
2 |
4 |
3 |
2 |
3 |
4 |
3 |
3 |
2 |
2 |
|
Transcription and RNA processing |
4 |
2 |
1 |
2 |
2 |
1 |
2 |
2 |
3 |
1 |
1 |
4 |
3 |
3 |
|
Translation, Translational regulation, post-translational and Protein modifications |
1 |
2 |
2 |
3 |
2 |
3 |
2 |
2 |
2 |
2 |
1 |
2 |
4 |
2 |
|
Gene regulation, operons, RNA interference, DNA methylation etc. |
4 |
2 |
2 |
3 |
2 |
2 |
3 |
3 |
2 |
3 |
3 |
3 |
3 |
1 |
|
Genomics & Application, Gene Therapy, Transgenic plants and animals, Mol markers and MAS |
1 |
2 |
3 |
4 |
6 |
3 |
4 |
3 |
4 |
3 |
4 |
3 |
4 |
3 |
|
Viral molecular genetics |
|
2 |
2 |
3 |
2 |
2 |
1 |
|
|
|
|
|
1 |
1 |
|
Total questions |
14 |
11 |
12 |
19 |
20 |
15 |
15 |
14 |
17 |
14 |
13 |
17 |
17 |
14 |
We hope this helps. An investment of time on this area of the syllabus is well worth the effort.
